Florian Rehfeldt

2023

L. Hauke*, A. Primeßnig, Benjamin Eltzner, Jennifer Radwitz, Stephan F. Huckemann, and F. Rehfeldt* (2023) FilamentSensor 2.0: An open-source modular toolbox for 2D/3D cytoskeletal filament tracking. PLoS ONE 18(2): e0279336. https://doi.org/10.1371/journal.pone.0279336
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F. Rehfeldt & Matthias Weiss (2023) The random walker’s toolbox for analyzing single-particle tracking data. Soft Matter in press
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L. Hauke, S. Isbaner, A. Ghosh, I. Guido, L. Turco, A.I. Chizhik, I. Gregor, N. Karedla*, F. Rehfeldt*, and Jörg Enderlein* (2023) Metal-Induced Energy Transfer (MIET) for Live-Cell Imaging with Fluorescent Proteins. ACS Nano, 17, 9, 8242–8251
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2022

Á. dos Santos, F. Rehfeldt*, and Christopher P. Toseland* (2022) Measuring Nuclear Mechanics with Atomic Force Microscopy. In: Leake, M.C. (eds) Chromosome Architecture. Methods in Molecular Biology, vol 2476. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2221-6_13
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2021

L. Hauke, S. Narasimhan, A. Primeßnig, I. Kaverina*, and F. Rehfeldt* (2021) A Focal Adhesion Filament Cross-correlation Kit for fast, automated segmentation and correlation of focal adhesions and actin stress fibers in cells. PLoS ONE 16: e0250749
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S. Kaliman, M. Hubert, C. Wollnik, L. Nuić, D. Vurnek, S. Gehrer, J. Lovrić, D. Dudziak, F. Rehfeldt*, and A.-S. Smith* (2021). Mechanical Regulation of Epithelial Tissue Homeostasis. Phys. Rev. X, 11, 031029; doi: 10.1103/PhysRevX.11.031029
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A. dos Santos, A.W. Cook, R.E. Gough, M. Schilling, N. Olszok, I. Brown, L. Wang, J. Aaron, L.M. Martin-Fernandez, F. Rehfeldt*, and C.P. Toseland* (2020) DNA damage alters nuclear mechanics through chromatin reorganization. Nucleic Acids Research 49: 340-353
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B. Pang, H. Liu, F. Rehfeldt, and K. Zhang (2021) High internal phase Pickering emulsions stabilized by dialdehyde amylopectin/chitosan complex nanoparticles. Carbohydrate Polymers 258: 117655
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2020

A.N. Gortari*, S. Bouchoule, E. Cambril, A. Cattoni, L. Hauke, J. Enderlein, F. Rehfeldt and A. Yacomotti (2020) Metasurface-based total internal reflection microscopy. Biomedical Optics Express, 11 (4): 1967-1976; doi: 10.1364/BOE.385276
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Eltzner, B., L. Hauke, S. Huckemann, F. Rehfeldt and C. Wollnik (2020). A Statistical and Biophysical Toolbox to Elucidate Structure and Formation of Stress Fibers. Nanoscale Photonic Imaging. T. Salditt, A. Egner and D. R. Luke. Cham, Springer International Publishing: 263-282. doi: 10.1007/978-3-030-34413-9_10
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Pang, B., H. Zhang, M. Schilling, H. Liu, X. Wang, F. Rehfeldt and K. Zhang (2020). High-Internal-Phase Pickering Emulsions Stabilized by Polymeric Dialdehyde Cellulose-Based Nanoparticles ACS Sustainable Chemistry & Engineering, 8(19): 7371-7379; doi: 10.1021/acssuschemeng.0c01116
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2019

Schlick, S. F., F. Spreckelsen, M. Tiburcy, L. M. Iyer, T. Meyer, L. C. Zelarayan, S. Luther, U. Parlitz, W.-H. Zimmermann* and F. Rehfeldt* (2019). Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium. Progress in Biophysics and Molecular Biology 144: 51-60
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L. Erpenbeck, A.L. Gruhn, G. Kudryasheva, G. Günay, D. Meyer, J. Busse, E. Neubert, M.P. Schön, F. Rehfeldt, and S. Kruss (2019) Effect of Adhesion and Substrate Elasticity on Neutrophil Extracellular Trap Formation. Frontiers in Immunology 10.
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Gottschalk, H. M., T. Wecker, M. H. Khattab, C. V. Fischer, J. Callizo, F. Rehfeldt, R. Lubjuhn, C. Russmann, H. Hoerauf and C. van Oterendorp (2019). Lipid Emulsion–Based OCT Angiography for Ex Vivo Imaging of the Aqueous Outflow TractLipid Emulsion-Based OCT Angiography. Investigative Ophthalmology & Visual Science 60(1): 397-406.
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Huang, H., X. Wang, J. Yu, Y. Chen, H. Ji, Y. Zhang, F. Rehfeldt, Y. Wang and K. Zhang (2019). Liquid-Behaviors-Assisted Fabrication of Multidimensional Birefringent Materials from Dynamic Hybrid Hydrogels. ACS Nano 13(4): 3867-3874.
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Wang, X., Huang, H., Liu, H., Rehfeldt, F., Wang, X., Zhang, K. (2019) Multi‐Responsive Bilayer Hydrogel Actuators with Programmable and Precisely Tunable Motions. Macromolecular Chemistry and Physics 220 (6) 1800562
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Delsing, P., A. N. Cleland, M. J. A. Schuetz, J. Knörzer, G. Giedke, J. I. Cirac, K. Srinivasan, M. Wu, K. C. Balram, C. Bäuerle, T. Meunier, C. J. B. Ford, P. V. Santos, E. Cerda-Méndez, H. Wang, H. J. Krenner, E. D. S. Nysten, M. Weiß, G. R. Nash, L. Thevenard, C. Gourdon, P. Rovillain, M. Marangolo, J.-Y. Duquesne, G. Fischerauer, W. Ruile, A. Reiner, B. Paschke, D. Denysenko, D. Volkmer, A. Wixforth, H. Bruus, M. Wiklund, J. Reboud, J. M. Cooper, Y. Fu, M. S. Brugger, F. Rehfeldt, and C. Westerhausen (2019). The 2019 surface acoustic waves roadmap. Journal of Physics D: Applied Physics 52(35): 353001.
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P. Brown, RELISH Consortium, Y. Zhou (2019) Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database
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H. Huang, Y. Yang, X. Wang, F. Rehfeldt, and K. Zhang (2019) Thermoresponsive Water Transportation in Dually Electrostatically Crosslinked Nanocomposite Hydrogels. Macromolecular Rapid Communications 40: 1900317.
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2018

Franz J, Grünebaum J, Schäfer M, Mulac D, F. Rehfeldt, Langer K, et al. (2018). Rhombic organization of microvilli domains found in a cell model of the human intestine. PLOS ONE; 13(1):e0189970
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Heidemann, K. M., A. O. Sageman-Furnas, A. Sharma, F. Rehfeldt, C. F. Schmidt and M. Wardetzky (2018). Topology determines force distributions in one-dimensional random spring networks. Physical Review E 97(2): 022306.
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Huang, H., X. Wang, F. Rehfeldt and K. Zhang (2018). Dually Heterogeneous Hydrogels via Dynamic and Supramolecular Cross-Links Tuning Discontinuous Spatial Ruptures. ACS Sustainable Chemistry & Engineering 6(3): 4294-4301.
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2017

F. Rehfeldt*, C.F. Schmidt.
Physical probing of cells. Journal of Physics D: Applied Physics. 2017;50(46):463001
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Buxboim A, Irianto J, Swift J, Athirasala A, Shin J-W, F. Rehfeldt, and Discher DE.
Coordinated increase of nuclear tension and lamin-A with matrix stiffness out-competes Lamin-B Receptor which favors soft tissue phenotypes. Molecular Biology of the Cell. 2017 September 20, 2017
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Bernhardt, M., J. D. Nicolas, M. Eckermann, B. Eltzner, F. Rehfeldt*, and T. Salditt*. 2017. Anisotropic x-ray scattering and orientation fields in cardiac tissue cells. New Journal of Physics 19:013012
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Huang, H., Y. Wang, X. Wang, F. Rehfeldt, and K. Zhang. 2017.
Robust Heterogeneous Hydrogels with Dynamic Nanocrystal–Polymer Interface.
Macromolecular Rapid Communications:1600810-n/a
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Benes, V., J. Vecera, B. Eltzner, C. Wollnik, F. Rehfeldt, V. Kralova, and S. Huckemann. 2017. Estimation of Parameters in a Planar Segment Process with a Biological Application. Image Analysis & Stereology 36:9
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Prabhune, M., F. Rehfeldt, and C. F. Schmidt; Molecular force sensors to measure stress in cells. Journal of Physics D: Applied Physics (2017) 50:233001
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2016

Bernhardt M., Priebe M., Osterhoff M., Wollnik C., Diaz A., Salditt T.*, Rehfeldt F.*
X-Ray Micro- and Nanodiffraction Imaging on Human Mesenchymal Stem Cells and Differentiated Cells. Biophysical Journal (2016) Volume 110, Issue 3, p680–690
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Prabhune, M., K. von Roden, F. Rehfeldt, and C. F. Schmidt. 2016.
Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. PLOS ONE 11:e0161623
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Kaliman S., Jayachandran C., Rehfeldt F., and Smith A.-S., Limits of Applicability of the Voronoi Tessellation Determined by Centers of Cell Nuclei to Epithelium Morphology, Front. Physiol., 25 November 2016
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Huckemann S., Kim K.-R., Munk A., Rehfeldt F., Sommerfeld M., Weickert J., Wollnik C.
The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation. Bernoulli Journal, Volume 22, Number 4 (2016), 2113-2142
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2015

Schlosser, F., F. Rehfeldt*, and Schmidt, C.F.* „Force Fluctuations in 3D suspended fibroblasts“, Philos. Trans. B. Roy. Soc. London (2015) 370 20140028; DOI: 10.1098/rstb.2014.0028
(selected as cover)
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Eltzner, B.*, Wollnik, C., Gottschlich, C., Huckemann, S., and F. Rehfeldt*
The filament sensor for near real-time detection of cytoskeletal fiber structures. PLoS One (2015), arXiv.org, 1408.4002
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Wardetzky, M., Heidemann, K., Sharma, A., Rehfeldt, F. and Schmidt, C.
F. „Elasticity of 3D networks with rigid filaments and compliant crosslinks“
Soft Matter, doi:10.1039/C4SM01789G (2015).
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Paluch, E., C. Nelson, N. Biais, B. Fabry, J. Moeller, B. Pruitt, C. Wollnik, G. Kudryasheva, F. Rehfeldt, and W. Federle: Mechanotransduction: use the force(s). BMC Biology 13:47 (2015)
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J. Altschuh, D. Lenoir, F. Rehfeldt, and R. Bruggemann: Applicability Domain of Nonlinear Property-Property Relationships – Example: Estimation of Vapour Pressure. MATCH Commun. Math. Comput. Chem. (2015)

2014

Kaliman, S., Jayachandran, C., F. Rehfeldt*, and Smith, A.S* (2014). Novel Growth Regime of MDCK II Model Tissues on Soft Substrates. Biophys. J., 106 (7), L25-L28 (selected for cover image)
abstract

Sandmann, R., S. S. G. Henriques, F. Rehfeldt and S. Köster,
„Micro-topography influences blood platelet spreading.“ Soft Matter, 2014.
abstract

Shin, J.-W., A. Buxboim, Kyle R. Spinler, J. Swift, David A. Christian, Christopher A. Hunter, C. Léon, C. Gachet, P. C. Dave P. Dingal, Irena L. Ivanovska, F. Rehfeldt, Joel A. Chasis and Dennis E. Discher (2014). „Contractile Forces Sustain and Polarize Hematopoiesis from Stem and Progenitor Cells.“ Cell Stem Cell.
abstract

2013

Swift, J., I. L. Ivanovska, A. Buxboim, T. Harada, P. C. D. P. Dingal, J. Pinter, J. D. Pajerowski, K. R. Spinler, J.-W. Shin, M. Tewari, F. Rehfeldt, D. W. Speicher and D. E. Discher (2013). Nuclear Lamin-A Scales with Tissue
Stiffness and Enhances Matrix-Directed Differentiation. Science, 2013, (341), 6149, doi 10.1126/science.1240104
abstract

2012

F. Rehfeldt*, Brown A.E.X., Raab M., Cai S.S., Zajac A.L., Zemel A., and Discher D.E.* (2012). Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells. Integrative Biology (4) p.422-430 DOI: 10.1039/c2ib00150k
abstract
Listed as Integrative Biology’s Top 2013 Cited Papers

2010

Zemel A., Rehfeldt F., Brown A.E.X., Discher D.E., Safran S.A.: „Cell shape, spreading symmetry, and the polarization of stress-fibers in cells“, J. Phys.: Condens. Matter, 2010 (22) 194110 DOI: 10.1088/0953-8984/22/19/194110
abstract

Zemel A.^$, Rehfeldt F.^$, Brown A.E.X., Discher D.E., Safran S.A.: „Optimal matrix rigidity for stress-fibre polarization in stem cells“, Nature Physics (21 March 2010) doi:10.1038/nphys1613 Article
^$ both authors contributed equally (A.Z. theory, F.R. experiment)
abstract

2009

Rehfeldt F., Engler A.J., and Discher D.E., Stem cells and nanomedicine: Nanomechanics of the microenvironment, in Nanotechnology, V. Vogel, Editor. 2009, Wiley VCH. (book chapter)
abstract

2008

Rossetti F.F., Panagiotou P., Rehfeldt F., Schneck E., Dommach M., Funari S.S., Timmann A., Muller-Buschbaum P., and Tanaka M.: „Structures of regenerated cellulose films revealed by grazing incidence small-angle x-ray scattering“, Biointerphases (3), p. 117-127 (2008)
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Schneck, E.; Rehfeldt, F.; Oliveira, R. G.; Gege, C.; Deme, B.; Tanaka, M., Modulation of intermembrane interaction and bending rigidity of biomembrane models via carbohydrates investigated by specular and off-specular neutron scattering. Physical Review E 2008, 78, (6), 061924-9.
abstract

2007

Rehfeldt F., Engler A.J., Eckhardt A., Ahmed F., Discher D.E.: „Cell responses to the mechanochemical microenvironment – Implications for regenerative medicine and drug delivery“. Advanced Drug Delivery Reviews, 2007, doi:10.1016/j.addr.2007.08.00.

Rehfeldt F. and Discher D.E.: „News and Views: Biophysics: Cell dipoles feel their way“. Nature Physics 2007 3 (9): 592-593.
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Engler A.J., Rehfeldt F., Sen S. and Discher D.E.: „Microtissue Elasticity: Measurements by Atomic Force Microscopy and Its Influence on Cell Differentiation“. Methods in Cell Biology, Academic Press 2007, Volume 83: 521-545.

2006

F. Rehfeldt*, Roland S., Armes S.P., von Klitzing R., Gast A.P., Tanaka M.*: „Reversible Activation of Diblock Copolymer Monolayers at the Interface by pH Modulation 2: Membrane Interactions at the Solid/Liquid Interface“. Journal of Physical Chemistry B 2006, 110, 9177 – 9182
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F. Rehfeldt*, Roland S., Armes S.P., von Klitzing R., Gast A.P., Tanaka M.*: „Reversible Activation of Diblock Copolymer Monolayers at the Interface by pH Modulation 1: Lateral Chain Density and Conformation“. Journal of Physical Chemistry B 2006, 110, 9171 – 9176
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2005

Tanaka M., Rehfeldt F., Schneider M.F., Mathe G., Albersdörfer A., Neumaier K.R., Purrucker O., Sackmann E.: „Wetting and dewetting of extracellular matrix and glycocalix models“. Journal of Physics: Condensed Matter 2005, 17, S649-S663
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Tanaka M., Rehfeldt F., Schneider M.F., Gege C., Schmidt R.R., Funari S.S.: „Oligomer-to-Polymer Transition in Short Ethylene Glycol Chains Connected to Mobile Hydrophobic Anchors“; ChemPhysChem 2005, 6, 101-109
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2004

Wong J.E., Rehfeldt F., Hanni P., Tanaka M., Klitzing R.V.: „Swelling behavior of polyelectrolyte multilayers in saturated water vapor“. Macromolecules 2004, 37, 7285-7289
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Tanaka M., Wong A.P., Rehfeldt F., Tutus M., Kaufmann S: „Selective deposition of native cell membranes on biocompatible micropatterns“; Journal of the American Chemical Society 2004, 126, 3257-3260
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2003 and before

Rehfeldt F., Tanaka M.: „Hydration forces in ultrathin films of cellulose“; Langmuir 2003, 19, 1467-1473
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Rehfeldt F., Tanaka M., Pagnoni L., Jordan R.: „Static and dynamic swelling of grafted poly (2-alkyl-2- oxazoline)s“. Langmuir 2002, 18, 4908-4914
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Niederfellner J., Lenoir D., Matuschek G., Rehfeldt F., Utschick H., Brüggemann R.: „Description of vapour pressures of polycyclic aromatic compounds by graph theoretical indices“; Quantitative Structure-Activity Relationships 1997, 16, 38-48
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* corresponding author

Book Chapters

Kendall K., Kendall M., Rehfeldt F. „Adhesion of Cells, Viruses and Nanoparticles“, 2010, Springer Netherlands, 1st Ed.

Rehfeldt F., A.J. Engler, and D.E. Discher, Stem Cells and Nanomedicine: Nanomechanics of the Microenvironment, in Nanotechnology, V. Vogel, Editor. 2009, Wiley VCH